SRC-Family Kinases, Inflammation, and Macrophage Responsiveness
This presentation is hosted by the Microbiology and Immunology Department.
Des Moines University faculty, staff, and students.
Cells in the immune system are tuned exquisitely to avoid the extremes of immunodeficiency and autoimmunity. We apply the tools of biochemistry and immunology to understand macrophage and lymphocyte signaling with the goal of understanding how inflammation and dysregulation can affect cell sensitivity and exacerbate disease, how protein-protein interactions at the plasma membrane regulate signaling, and how receptor clustering enables signaling.
Tanya Freedman, PhD
Assistant Professor, Department of Pharmacology, University of Minnesota
Immune cells are tuned exquisitely to identify pathogens and avoid hypersensitivity. In macrophages the Src-family tyrosine kinases (LynA, LynB, Hck, and Fgr) regulate a size sensing mechanism based on their ability to nucleate ITAM receptor clusters. Bacteria and yeast cells are a few microns in diameter, and resulting micron-sized ITAM clusters trigger strong antimicrobial signaling. We are studying how regulation of the Src-family kinases, especially LynA, regulate the receptor-ligand size threshold that sometimes results in macrophage hypersensitivity to smaller stimuli. We are also interested in how LynA and other signaling proteins contribute to macrophage roles in autoinflammation, tumor growth, and antimicrobial responses. Full biography.
Des Moines University is located on a 22-acre campus in the heart of Des Moines, Iowa. Just west of downtown on Grand Avenue, the University is located in one of Des Moines' most prestigious neighborhoods. The campus is in a historic neighborhood filled with tree-lined streets and gracious older homes and businesses. Its central location makes it easy to access the rest of the city and outlying communities. The campus is close to the Des Moines International Airport, located on the bus line and just blocks from local shopping and downtown Des Moines.
- 1.00 CE Contact Hours