The Effect of Nucleosome Conformation on Histone Tail Binding - Implications for Chromatin Signaling
Des Moines University faculty, staff, and students.
- Explain what is meant by chromatin signaling.
- Describe what histone reader domains are.
- Describe new developments in nucleosome structure.
Catherine Musselman, Ph.D.
Assistant Professor, Biochemistry, University of Iowa
Dr. Musselman’s research program is aimed at understanding molecular mechanisms of chromatin regulation and how dysregulation of these pathways contributes to disease. Specifically, she seeks to understand, on the structural and thermodynamic level, how reader domains selectively associate with modified nucleosomes, with a long-term goal of understanding how multiple reader domains work together to allow chromatin regulatory complexes to navigate and respond to the dynamic chromatin landscape. Dr. Musselman’s expertise is in NMR spectroscopy, she also utilizes X-ray crystallography, Fluorescence Polarization, and Biolayer Interferometry
Des Moines University is located on a 22-acre campus in the heart of Des Moines, Iowa. Just west of downtown on Grand Avenue, the University is located in one of Des Moines’ most prestigious neighborhoods. The campus is in a historic neighborhood filled with tree-lined streets and gracious older homes and businesses. Its central location makes it easy to access the rest of the city and outlying communities. The campus is close to the Des Moines International Airport, located on the bus line and just blocks from local shopping and downtown Des Moines.
- 1.00 CE Contact Hour(s)