Target Audience

Des Moines University faculty, staff, and students.

Topics

Investigation of Statin Actions on Signal Transduction Pathways in an Aggressive Natural Killer Cell Leukemia Cell Line

• Differentiate between cases of natural killer cell leukemia, their symptoms, and prognosis when compared to other lymphomas.
• Describe previous research involving statins as a tool in cancer treatment.
• Analyze and question the mechanisms by which statins act on signal transduction pathways in NK cell leukemia.
• Have an ability to interpret a human Phospho-MAPK array.

Identification and Characterization of Calmodulin-Binding Domains in the Angiotensin II Receptor 1A

• Identify how FRET based biosensors offer an exhaustive approach to identify potential calmodulin binding domains of the angiotensin II receptor 1A (AT1R).
• Demonstrate how our methods, in combination with FRET based biosensors and suitable Ca2+ indicators, allows precise assessment of the Ca2+ sensitivity between CaM and its partners, which is useful in predicting physiological function.

Speakers

Kevin Ehlers, MBS-17

Ashley Yingst, MBS-17